The Sequence patches are designed for a certain key, so you'll need to change the key to work in the key you'd like to use it in. Because of that, there's one octave of notes - so there will be one note in the scale that work. So if that sequence pictured is set for C, the lower C, D, E, F, G, A, B will play but the extra octave allows it to be transposed to any other key, so that layer range allows for that.
